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As Cameron mentioned, real time communication apps with no downloads or plugins required - everything you need's built-in to the browser. Chrome's integrating webrtc now, and per their real time comms lead Google+ Hangout will be webrtc based soon.
the biggest potential losers from widescale adoption of webrtc are communication apps that don't evolve to support it. Skype comes to mind here, but they're heavily involved in webrtc so it's probably safe to say they'll be adopting it aggressively - in pace with IE.